Publications

 

2015

Lorincz P, Takats S, Karpati M, Juhasz G. iFly: The eye of the fruit fly as a model to study autophagy and related trafficking pathways. Exp Eye Res. 2015 Jun 16. pii: S0014-4835(15)00201-8.

Kim M, Semple I, Kim B, Kiers A, Nam S, Park HW, Park H, Ro SH, Kim JS, Juhasz G, Lee JH. Drosophila Gyf/GRB10 interacting GYF protein is an autophagy regulator that controls neuron and muscle homeostasis. Autophagy. 2015 Jun 18:0. [Epub ahead of print]

Takats S, Varga A, Pircs K, Juhasz G. Loss of Drosophila Vps16A enhances autophagosome formation through reduced TOR activity. Autophagy. 2015 Jun 10:0. [Epub ahead of print]

Mauvezin C, Nagy P, Juhasz G, Neufeld TP. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015 May 11;6:7007.

Nagy P, Varga A, Kovacs AL, Takats S, Juhasz G. How and why to study autophagy in Drosophila: it's more than just a garbage chute. Methods. 2015 Mar;75:151-61.

 

2014

Takats S, Pircs K, Nagy P, Varga A, Karpati M, Hegedus K, Kramer H, Kovacs AL, Sass M, Juhasz G. Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell. 2014 Apr;25(8):1338-54.

Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Kuttner V, Bhukel A, Marino G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Buttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Frohlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab. 2014 Mar 4;19(3):431-44.

Hegedus K, Nagy P, Gaspari Z, Juhasz G. The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila. Biomed Res Int. 2014; 470482.

Molnar I, Migh E, Szikora S, Kalmar T, Vegh AG, Deak F, Barko S, Bugyi B, Orfanos Z, Kovacs J, Juhasz G, Varo G, Nyitrai M, Sparrow J, Mihaly J. DAAM is required for thin filament formation and sarcomerogenesis during muscle development in Drosophila PLoS Genet. 2014 Feb 27;10(2):e1004166.

Nagy P, Karpati M, Varga A, Pircs K, Venkei Z, Takats S, Varga K, Erdi B, Hegedus K, Juhasz G. Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila. Autophagy. 2014 March;10(3):453-467.

Szatmari Z, Kis V, Lippai M, Hegedus K, Farago T, Lorincz P, Tanaka T, Juhasz G, Sass M. Rab11 facilitates crosstalk between autophagy and endosomal pathway through regulation of Hook localization. Mol Biol Cell. 2014 Feb;25(4):522-31.

Mulakkal NC, Nagy P, Takats S, Tusco R, Juhasz G, Nezis IP. Autophagy in Drosophila: from historical studies to current knowledge. Biomed Res Int. 2014; 273473.

Nagy P, Hegedus K, Pircs K, Varga A, Juhasz G. Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila. FEBS Lett. 2014 Jan 31;588(3):408-13.

 

2013

Nagy P, Varga A, Pircs K, Hegedus K, Juhasz G. Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster. PLoS Genet. 2013 Aug;9(8):e1003664.

Low P, Varga A, Pircs K, Nagy P, Szatmari Z, Sass M, Juhasz G. Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila. BMC Cell Biol. 2013 Jun 25;14(1):29.

Hegedus K., Takats S., Kovacs Al., Juhasz G. Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (syntaxin 17)-containing SNARE complex in autophagosome fusion with endosomes and lysosomes Autophagy. 2013 Oct;9(10):1642-1646

Takats S., Juhasz G. A genetic model with specifically impaired autophagosome-lysosome fusion. Autophagy. 2013 Jun 25;9(8).

Takats S, Nagy P, Varga A, Pircs K, Karpati M, Varga K, Kovacs AL, Hegedus K, Juhasz G. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol. 2013 May 13;201(4):531-9.

Juhasz G, Puertollano R, Shimizu S, Vaccaro MI. Autophagy researchers. Autophagy. 2013 Jun 1;9(6):815-8.

 

2012

Pircs K, Nagy P, Varga A, Venkei Z, Erdi B, Hegedus K, Juhasz G. Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila PLoS ONE. 2012;7(8):e44214.

Juhasz G. Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: Novel considerations. Autophagy. 2012 Dec 1;8(12).

Erdi B, Nagy P, Zvara A, Varga A, Pircs K, Menesi D, Puskas LG, Juhasz G. Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. Autophagy. 2012 Jul 1;8(7).

Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012; 8:445-544

Venkei Z, Przewloka MR, Ladak Y, Albadri S, Sossick A, Juhasz G, Novak B, Glover DM. Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore. Open Biol. 2012; 2:110032.

Kelemen-Valkony I, Kiss M, Csiha J, Kiss A, Bircher U, Szidonya J, Maroy P, Juhasz G, Komonyi O, Csiszar K, Mink M. Drosophila basement membrane collagen col4a1 mutations cause severe myopathy. Matrix Biol. 2012 Jan;31(1):29-37.

 

2009

Csikos G, Lippai M, Lukacsovich T, Juhasz G, Henn L, Erdelyi M, Maroy P, Sass M. A novel role for the Drosophila epsin (lqf): involvement in autophagy. Autophagy. 2009; 5(5):636-48.

Chang YY, Juhasz G, Goraksha-Hicks P, Arsham AM, Mallin DR, Muller LK, Neufeld TP. Nutrient-dependent regulation of autophagy through the target of rapamycin pathway. Biochem Soc Trans. 2009;37(Pt 1):232-6.

 

2008

Juhasz G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol. 2008 May 19;181(4):655-66.

Lippai M, Csikos G, Maroy P, Lukacsovich T, Juhasz G, Sass M. SNF4Agamma, the Drosophila AMPK gamma subunit is required for regulation of developmental and stress-induced autophagy. Autophagy. 2008 Jul-Aug;4(4):476-86. Epub 2008 Feb 13.

Juhasz G, Neufeld TP. Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis. Autophagy. 2008 Apr 1;4(3):357-8. Epub 2008 Jan 15.

Juhasz G, Neufeld TP Experimental control and assessment of autophagy in Drosophila In: Deretic V (ed.) Methods in Molecular Biology: Autophagosome and phagosome, Humana Press, Totowa, NJ, USA, 445:125-33 (2008)

 

2007

Juhasz G, Erdi B, Sass M, Neufeld TP. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 2007 Dec 1;21(23):3061-6.

Juhasz G, Puskas LG, Komonyi O, Erdi B, Maroy P, Neufeld TP, Sass M. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ. 2007 Jun;14(6):1181-90.

Papp AM, Nyilas R, Szepesi Z, Lorincz ML, Takacs E, Abraham I, Szilagyi N, Toth J, Medveczky P, Szilagyi L, Juhasz G, Juhasz G. Visible light induces matrix metalloproteinase-9 expression in rat eye. J Neurochem. 2007 Dec;103(6):2224-33.

Scott RC, Juhasz G, Neufeld TP. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol. 2007 Jan 9;17(1):1-11.

 

2006

Akdemir F, Farkas R, Chen P, Juhasz G, Medvedova L, Sass M, Wang L, Wang X, Chittaranjan S, Gorski SM, Rodriguez A, Abrams JM. Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death. Development. 2006 Apr;133(8):1457-65.

Juhasz G, Neufeld TP. Autophagy: a forty-year search for a missing membrane source. PLoS Biol. 2006 Feb;4(2):161-64.

 

2005

Juhasz G, Sass M. Hid can induce, but is not required for autophagy in polyploid larval Drosophila tissues. Eur J Cell Biol. 2005 Apr;84(4):491-502.

 

2004

Rusten TE, Lindmo K, Juhasz G, Sass M, Seglen PO, Brech A, Stenmark H. Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell. 2004 Aug;7(2):179-92.

 

2003

Juhasz G, Csikos G, Sinka R, Erdelyi M, Sass M. The Drosophila homolog of Aut1 is essential for autophagy and development. FEBS Lett. 2003 May 22;543(1-3):154-8.

 

2001

Juhasz G, Csikos G, Sass M. A possible approach to study autophagy in Drosophila. Acta Biol Hung. 2001;52(4):485-90.