Selected Publications

Please follow the links at the opening (first) page for a full list of our papers.

Csizmadia T, Lorincz P, Hegedus K, Szeplaki S, Low P, Juhasz G. Molecular mechanisms of developmentally programmed crinophagy in Drosophila. J Cell Biol. 2017 Oct 24. pii: jcb.201702145.

Nagy P, Szatmari Z, Sandor GO, Lippai M, Hegedus K, Juhasz G. Drosophila Atg16 promotes enteroendocrine cell differentiation via regulation of intestinal Slit/Robo signaling. Development. 2017 Nov 1;144(21):3990-4001.

Lorincz P, Toth S, Benko P, Lakatos Z, Boda A, Glatz G, Zobel M, Bisi S, Hegedus K, Takats S, Scita G, Juhasz G. Rab2 promotes autophagic and endocytic lysosomal degradation. J Cell Biol. 2017 Jul 3;216(7):1937-1947. doi: 10.1083/jcb.201611027

Katheder NS, Khezri R, O'Farrell F, Schultz SW, Jain A, Rahman MM, Schink KO, Theodossiou TA, Johansen T, Juhasz G, Bilder D, Brech A, Stenmark H, Rusten TE. Microenvironmental autophagy promotes tumour growth. Nature. 2017 Jan 19;541(7637):417-420. doi: 10.1038/nature20815.

Varga K, Nagy P, Arsikin Csordas K, Kovacs AL, Hegedus K, Juhasz G. Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila. Sci Rep. 2016 Oct 6;6:34641. doi: 10.1038/srep34641

Hegedus K, Takats S, Boda A, Jipa A, Nagy P, Varga K, Kovacs AL, Juhasz G. The Ccz1-Mon1-Rab7 module and Rab5 control distinct steps of autophagy. Mol Biol Cell. 2016 Oct 15;27(20):3132-3142

Lorincz P, Lakatos Z, Varga A, Maruzs T, Simon-Vecsei Z, Darula Z, Benko P, Csordas G, Lippai M, Ando I, Hegedus K, Medzihradszky KF, Takats S, Juhasz G. MiniCORVET is a Vps8-containing early endosomal tether in Drosophila. Elife. 2016 Jun 2;5. pii: e14226. doi: 10.7554/eLife.14226.

Kim M, Sandford E, Gatica D, Qiu Y, Liu X, Zheng Y, Schulman BA, Xu J, Semple I, Ro SH, Kim B, Mavioglu RN, Tolun A, Jipa A, Takats S, Karpati M, Li JZ, Yapici Z, Juhasz G, Lee JH, Klionsky DJ, Burmeister M. Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay. Elife. 2016 Jan 26;5. pii: e12245. doi: 10.7554/eLife.12245.

Mauvezin C, Nagy P, Juhasz G, Neufeld TP. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015 May 11;6:7007. doi: 10.1038/ncomms8007.

Nagy P, Varga A, Kovacs AL, Takats S, Juhasz G. How and why to study autophagy in Drosophila: it's more than just a garbage chute. Methods. 2015 Mar;75:151-61.

Takats S, Pircs K, Nagy P, Varga A, Karpati M, Hegedus K, Kramer H, Kovacs AL, Sass M, Juhasz G. Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila. Mol Biol Cell. 2014 Apr;25(8):1338-54.

Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Kuttner V, Bhukel A, Marino G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Buttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Frohlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metab. 2014 Mar 4;19(3):431-44.

Nagy P, Karpati M, Varga A, Pircs K, Venkei Z, Takats S, Varga K, Erdi B, Hegedus K, Juhasz G. Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila. Autophagy. 2014 March;10(3):453-467.

Szatmari Z, Kis V, Lippai M, Hegedus K, Farago T, Lorincz P, Tanaka T, Juhasz G, Sass M. Rab11 facilitates crosstalk between autophagy and endosomal pathway through regulation of Hook localization. Mol Biol Cell. 2014 Feb;25(4):522-31.

Nagy P, Varga A, Pircs K, Hegedus K, Juhasz G. Myc-Driven Overgrowth Requires Unfolded Protein Response-Mediated Induction of Autophagy and Antioxidant Responses in Drosophila melanogaster. PLoS Genet. 2013 Aug;9(8):e1003664.

Takats S, Nagy P, Varga A, Pircs K, Karpati M, Varga K, Kovacs AL, Hegedus K, Juhasz G. Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila. J Cell Biol. 2013 May 13;201(4):531-9.

Pircs K, Nagy P, Varga A, Venkei Z, Erdi B, Hegedus K, Juhasz G. Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila PLoS ONE. 2012;7(8):e44214.

Erdi B, Nagy P, Zvara A, Varga A, Pircs K, Menesi D, Puskas LG, Juhasz G. Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. Autophagy. 2012 Jul 1;8(7).

Juhasz G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol. 2008 May 19;181(4):655-66.

Juhasz G, Erdi B, Sass M, Neufeld TP. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 2007 Dec 1;21(23):3061-6.

Juhasz G, Puskas LG, Komonyi O, Erdi B, Maroy P, Neufeld TP, Sass M. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ. 2007 Jun;14(6):1181-90.

Scott RC, Juhasz G, Neufeld TP. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr Biol. 2007 Jan 9;17(1):1-11.

Juhasz G, Neufeld TP. Autophagy: a forty-year search for a missing membrane source. PLoS Biol. 2006 Feb;4(2):161-64.

Rusten TE, Lindmo K, Juhasz G, Sass M, Seglen PO, Brech A, Stenmark H. Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell. 2004 Aug;7(2):179-92.

Juhasz G, Csikos G, Sinka R, Erdelyi M, Sass M. The Drosophila homolog of Aut1 is essential for autophagy and development. FEBS Lett. 2003 May 22;543(1-3):154-8.